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Overall survival (OS) for melanoma is improving equally rapidly, 2 with dramatic increases in long-term survival observed with administration of these new therapies. 1 In < 10 years, nine new drugs have been approved for unresectable melanoma, along with four new approvals in the adjuvant setting. Systemic treatment of melanoma has changed rapidly since the introduction of ipilimumab in 2011. Lee Moffitt Cancer Center and Research Institute, Tampa, FLĢ3University of North Carolina School of Medicine, Chapel Hill, NCĢ4Gustave Roussy Cancer Centre, Villejuif, FranceĢ5Paris-Saclay University, Villejuif, FranceĢ6Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, ItalyĢ7Indiana University School of Medicine, Indianapolis, INĢ9Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CAģ0Netherlands Cancer Institute, Amsterdam, the Netherlands

1State University of New York Upstate Medical University, Syracuse, NYĢAmerican Society of Clinical Oncology, Alexandria, VAģUniversity of Virginia, Charlottesville, VAĤUniversity of Pittsburgh School of Medicine, Pittsburgh, PAĥUniversity of Pittsburgh Medical Center, Hillman Cancer Institute, Pittsburgh, PAħUniversity of Texas MD Anderson Cancer Center, Houston, TXĨColumbia Presbyterian Clinical Associates, Bronxville, NYĩHuntsman Cancer Institute, University of Utah, Salt Lake City, UTġ0Laura and Isaac Perlmutter Cancer Center at New York University, Langone Health, New York, NYġ1St Luke’s Mountain States Tumor Institute, Boise, IDġ2Lewis Katz School of Medicine at Temple University, Philadelphia, PAġ3Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italyġ4Georgetown-Lombardi Comprehensive Cancer Center, Washington, DCġ5Vanderbilt University Medical Center, Nashville, TNġ6Roswell Park Cancer Institute, Buffalo, NYġ7The Angeles Clinic and Research Institute, Los Angeles, CAġ8Cedars Sinai Medical Center, Los Angeles, CAġ9Veterans Administration Boston Healthcare System, West Roxbury, MAĢ1Peter MacCallum Cancer Centre, Melbourne, Victoria, AustraliaĢ2H.